Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer.

ABSTRACT: The NF-κB family of transcription factors regulate the expression of genes encoding proteins and microRNAs (miRNA, miR) precursors that may either positively or negatively regulate a variety of biological processes such as cell cycle progression, cell survival, and cell differentiation. The NF-κB-miRNA transcriptional regulatory network has been implicated in the regulation of proinflammatory, immune, and stress-like responses. Gene regulation by miRNAs has emerged as an additional epigenetic mechanism at the post-transcriptional level. The expression of miRNAs can be regulated by specific transcription factors (TFs), including the NF-κB TF family, and vice versa. The interplay between TFs and miRNAs creates positive or negative feedback loops and also regulatory networks, which can contro

SUBMITTER: Markopoulos GS 

PROVIDER: S-EPMC6027290 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature