Challenges for the Self-Assembly of Poly(Ethylene Glycol)⁻Poly(Lactic Acid) (PEG-PLA) into Polymersomes: Beyond the Theoretical Paradigms.

ABSTRACT: Polymersomes (PL), vesicles formed by self-assembly of amphiphilic block copolymers, have been described as promising nanosystems for drug delivery, especially of biomolecules. The film hydration method (FH) is widely used for PL preparation, however, it often requires long hydration times and commonly results in broad size distribution. In this work, we describe the challenges of the self-assembly of poly (ethylene glycol)-poly(lactic acid) (PEG-PLA) into PL by FH exploring different hydrophilic volume fraction (f) values of this copolymer, stirring times, temperatures and post-FH steps in an attempt to reduce broad size distribution of the nanostructures. We demonstrate that, alongside f value, the methods employed for hydration and post-film steps influence the PEG-PLA self-assembly int

SUBMITTER: Apolinario AC 

PROVIDER: S-EPMC6027356 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature