Efficient Computational Design of a Scaffold for Cartilage Cell Regeneration.

ABSTRACT: Due to the sensitivity of mammalian cell cultures, understanding the influence of operating conditions during a tissue generation procedure is crucial. In this regard, a detailed study of scaffold based cell culture under a perfusion flow is presented with the aid of mathematical modelling and computational fluid dynamics (CFD). With respect to the complexity of the case study, this work focuses solely on the effect of nutrient and metabolite concentrations, and the possible influence of fluid-induced shear stress on a targeted cell (cartilage) culture. The simulation set up gives the possibility of predicting the cell culture behavior under various operating conditions and scaffold designs. Thereby, the exploitation of the predictive simulation into a newly developed stochastic routine pr

SUBMITTER: Tajsoleiman T 

PROVIDER: S-EPMC6027378 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature