Transcriptome Analysis of Acute Phase Liver Graft Injury in Liver Transplantation.

ABSTRACT: Liver transplantation remains the treatment of choice for a selected group of hepatocellular carcinoma (HCC) patients. However, the long-term benefit is greatly hampered by post-transplant HCC recurrence. Our previous studies have identified liver graft injury as an acute phase event leading to post-transplant tumor recurrence. To re-examine this acute phase event at the molecular level and in an unbiased way, RNA sequencing (RNA-Seq) was performed on liver graft biopsies obtained from the transplant recipients two hours after portal vein reperfusion with an aim to capture frequently altered pathways that account for post-transplant tumor recurrence. Liver grafts from recurrent recipients (n = 6) were sequenced and compared with those from recipients without recurrence (n = 5). RNA express

SUBMITTER: Lee NP 

PROVIDER: S-EPMC6027418 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature