Investigation of Daphnia magna Sub-Lethal Exposure to Organophosphate Esters in the Presence of Dissolved Organic Matter Using ¹H NMR-Based Metabolomics.

ABSTRACT: Organophosphate esters (OPEs) are frequently detected in aquatic environments. Hydrophobic OPEs with high octanol-water partition coefficients (Log KOW) will likely sorb to dissolved organic matter (DOM) and consequently alter OPE bioavailability and sub-lethal toxicity. ¹H nuclear magnetic resonance (NMR)-based metabolomics was used to evaluate how DOM (5 mg organic carbon/L) alters the metabolic response of Daphnia magna exposed to sub-lethal concentrations of three individual OPEs with varying hydrophobicity. D. magna exposed to the hydrophilic contaminant (Log KOW = 1.43) tris(2-chloroethyl) phosphate (TCEP) did not have substantial metabolic changes and DOM did not alter the metabolic response. There were significant increases in amino acids and a decrease in glucose from exposure to

SUBMITTER: Kovacevic V 

PROVIDER: S-EPMC6027453 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature