Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development.

ABSTRACT: The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived fr

SUBMITTER: Rubenstein E 

PROVIDER: S-EPMC6027594 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature