Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis.

ABSTRACT:

Purpose

Since electroporation (EP) can increase the permeability of biological membranes, we hypothesized that it offers an opportunity to enhance the transdermal delivery of drugs for intra-articular indications. Our aim was to compare the anti-inflammatory and analgesic efficacy of EP-combined topical administration of diclofenac sodium hydrogel (50 mg mL^-1 in 230 µL volume) with that of an equivalent dose of oral (75 mg kg^-1) and simple topical administration.

Methods

Arthritis was induced with the injection of 2% λ-carrageenan and 4% kaolin into the right knee joints of male Sprague Dawley rats. EP was applied for 8 min with 900 V high-voltage pulses for 5 ms followed by a 20 ms break. Drug penetration into the synovial fluid and plasma was detected

SUBMITTER: Hartmann P 

PROVIDER: S-EPMC6027698 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature