Identification of differentially expressed genes and pathways in mice exposed to mixed field neutron/photon radiation.

ABSTRACT:

Background

Radiation exposure due to the detonation of an improvised nuclear device remains a major security concern. Radiation from such a device involves a combination of photons and neutrons. Although photons will make the greater contribution to the total dose, neutrons will certainly have an impact on the severity of the exposure as they have high relative biological effectiveness.

Results

We investigated the gene expression signatures in the blood of mice exposed to 3 Gy x-rays, 0.75 Gy of neutrons, or to mixed field photon/neutron with the neutron fraction contributing 5, 15%, or 25% of a total 3 Gy radiation dose. Gene ontology and pathway analysis revealed that genes involved in protein ubiquitination pathways were significantly overrepresented in all radiation dose

SUBMITTER: Broustas CG 

PROVIDER: S-EPMC6027792 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature