Dataset Information

Direct modulation of myelin-autoreactive CD4⁺ and CD8⁺ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules.

ABSTRACT:

Purpose

Numerous nanomaterials have been reported in the treatment of multiple sclerosis or experimental autoimmune encephalomyelitis (EAE). But most of these nanoscale therapeutics deliver myelin antigens together with toxins or cytokines and underlay the cellular uptake and induction of tolerogenic antigen-presenting cells by which they indirectly induce T cell tolerance. This study focuses on the on-target and direct modulation of myelin-autoreactive T cells and combined use of multiple regulatory molecules by generating a tolerogenic nanoparticle.

Materials and methods

Poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) were fabricated by co-coupling MOG_40-54/H-2D^b-Ig dimer, MOG_35-55/I-A^b multimer, anti-Fas, PD-L1-Fc and CD4

SUBMITTER: Pei W

PROVIDER: S-EPMC6027825 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Dataset Information

Direct modulation of myelin-autoreactive CD4⁺ and CD8⁺ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules.

Purpose

Materials and methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules.

Purpose

Materials and methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Direct modulation of myelin-autoreactive CD4⁺ and CD8⁺ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules.