Combining Cognitive, Genetic, and Structural Neuroimaging Markers to Identify Individuals with Increased Dementia Risk.

ABSTRACT:

Background

Cognitive and biological markers have shown varying degrees of success in identifying persons who will develop dementia.

Objective

To evaluate different combinations of cognitive and biological markers and identify prediction models with the highest accuracy for identifying persons with increased dementia risk.

Methods

Neuropsychological assessment, genetic testing (apolipoprotein E -APOE), and structural magnetic resonance imaging (MRI) were performed for 418 older individuals without dementia (60-97 years) from a population-based study (SNAC-K). Participants were followed for six years.

Results

Cognitive, genetic, and MRI markers were systematically combined to create prediction models for dementia at six years. The most predictive individual marke

SUBMITTER: Payton NM 

PROVIDER: S-EPMC6027943 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature