Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [¹¹C]PBR28 study.

ABSTRACT: Patients with schizophrenia show whole brain and cortical gray matter (GM) volume reductions which are progressive early in their illness. Microglia, the resident immune cells in the CNS, phagocytose neurons and synapses. Some post mortem and in vivo studies in schizophrenia show evidence for elevated microglial activation compared to matched controls. However, it is currently unclear how these results relate to changes in cortical structure.

Methods

Fourteen patients with schizophrenia and 14 ultra high risk for psychosis (UHR) subjects alongside two groups of age and genotype matched healthy controls received [¹¹C]PBR28 PET scans to index TSPO expression, a marker of microglial activation and a 3T MRI scan. We investigated the relationship between the volume changes of

SUBMITTER: Selvaraj S 

PROVIDER: S-EPMC6027955 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature