Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression.

ABSTRACT: Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies of healing. Here, we investigate the cellular interactions between innate immune cells and endothelial cells at wounds that drive neoangiogenic sprouting in real time and in vivo Our studies in mouse and zebrafish wounds indicate that macrophages are drawn to wound blood vessels soon after injury and are intimately associated throughout the repair process and that macrophage ablation results in impaired neoangiogenesis. Macrophages also positively influence wound angiogenesis by driving resolution of anti-angiogenic wound neutrophils. Experimental manipulation of the wound environment to specifically alter macrophage activation state dramatically influences subsequent blood vessel sprouting, with pr

SUBMITTER: Gurevich DB 

PROVIDER: S-EPMC6028026 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature