<i>In vivo</i> expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors.

ABSTRACT: A central hypothesis for brain evolution is that it might occur via expansion of progenitor cells and subsequent lineage-dependent formation of neural circuits. Here, we report in vivo amplification and functional integration of lineage-specific circuitry in Drosophila Levels of the cell fate determinant Prospero were attenuated in specific brain lineages within a range that expanded not only progenitors but also neuronal progeny, without tumor formation. Resulting supernumerary neural stem cells underwent normal functional transitions, progressed through the temporal patterning cascade, and generated progeny with molecular signatures matching source lineages. Fully differentiated supernumerary gamma-amino butyric acid (GABA)-ergic interneurons formed functional connections i

SUBMITTER: Shaw RE 

PROVIDER: S-EPMC6028031 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature