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Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.

ABSTRACT: The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from preclinical and clinical data. In particular, we discuss the mechanism by which IL-23 promotes tumor growth and metastases and how the IL-12/IL-23 axis of inflammation can be targeted for cancer therapy.

SUBMITTER: Yan J 

PROVIDER: S-EPMC6028064 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.

Yan Juming J   Smyth Mark J MJ   Teng Michele W L MWL  

Cold Spring Harbor perspectives in biology 20180702 7

The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from preclinical and clinical data. In particular, we discuss the mechanism by which IL-23 promotes tumor growth and metastases and how the IL-12/IL-23 axis of inflammation can be targeted for cancer therapy. ...[more]

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