Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer.

ABSTRACT: Most breast cancer deaths are caused by metastasis and treatment options beyond radiation and cytotoxic drugs, which have severe side effects, and hormonal treatments, which are or become ineffective for many patients, are urgently needed. This study reanalyzed existing data from three genome-wide association studies (GWAS) using a novel computational biostatistics approach (muGWAS), which had been validated in studies of 600-2000 subjects in epilepsy and autism. MuGWAS jointly analyzes several neighboring single nucleotide polymorphisms while incorporating knowledge about genetics of heritable diseases into the statistical method and about GWAS into the rules for determining adaptive genome-wide significance. Results from three independent GWAS of 1000-2000 subjects each, which were made

SUBMITTER: Wittkowski KM 

PROVIDER: S-EPMC6028090 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature