Human long intrinsically disordered protein regions are frequent targets of positive selection.

ABSTRACT: Intrinsically disordered regions occur frequently in proteins and are characterized by a lack of a well-defined three-dimensional structure. Although these regions do not show a higher order of structural organization, they are known to be functionally important. Disordered regions are rapidly evolving, largely attributed to relaxed purifying selection and an increased role of genetic drift. It has also been suggested that positive selection might contribute to their rapid diversification. However, for our own species, it is currently unknown whether positive selection has played a role during the evolution of these protein regions. Here, we address this question by investigating the evolutionary pattern of more than 6600 human proteins with intrinsically disordered regions and their order

SUBMITTER: Afanasyeva A 

PROVIDER: S-EPMC6028134 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature