Inherited DNA methylation primes the establishment of accessible chromatin during genome activation.

ABSTRACT: For animals, epigenetic modifications can be globally or partially inherited from gametes after fertilization, and such information is required for proper transcriptional regulation, especially during the process of zygotic genome activation (ZGA). However, the mechanism underlying how the inherited epigenetic signatures affect transcriptional regulation during ZGA remains poorly understood. Here, we performed genome-wide profiling of chromatin accessibility during zebrafish ZGA, which is closely related to zygotic transcriptional regulation. We observed a clear trend toward a gradual increase in accessible chromatin during ZGA. Furthermore, accessible chromatin at the promoters displayed a sequential priority of emergence, and the locations of the accessible chromatin were precisely prime

SUBMITTER: Liu G 

PROVIDER: S-EPMC6028135 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature