Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.

ABSTRACT: Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Our current understanding of the detailed organization of cell membranes remains rather elusive, because of the challenge to study fluctuating nanoscale assemblies of lipids and proteins with the required spatiotemporal resolution. Here, we use molecular dynamics simulations to characterize the lipid environment of 10 different membrane proteins. To provide a realistic lipid environment, the proteins are embedded in a model plasma membrane, where more than 60 lipid species are represented, asymmetrically distributed between the leaflets. The simulations detail how each protein modulates its local lipid environment in a unique way, through enrichment or depletion of specific lipid components, resu

SUBMITTER: Corradi V 

PROVIDER: S-EPMC6028153 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature