^86/90Y-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model.

ABSTRACT: Angiogenesis is widely recognized as one of the hallmarks of cancer. Therefore, imaging and therapeutic agents targeted to angiogenic vessels may be widely applicable in many types of cancer. To this end, the theranostic isotope pair, ⁸⁶Y and ⁹⁰Y, were used to create a pair of agents for targeted imaging and therapy of neovasculature in murine breast cancer models using a chimeric anti-CD105 antibody, TRC105. Serial positron emission tomography imaging with ⁸⁶Y-DTPA-TRC105 demonstrated high uptake in 4T1 tumors, peaking at 9.6 ± 0.3%ID/g, verified through ex vivo studies. Additionally, promising results were obtained in therapeutic studies with ⁹⁰Y-DTPA-TRC105, wherein significantly ( p < 0.05) decreased tumor volumes were observed for the target

SUBMITTER: Ehlerding EB 

PROVIDER: S-EPMC6028311 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature