Arterial-spin-labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: A 4-year longitudinal study.

ABSTRACT:

Background

With the disappointing outcomes of clinical trials on patients with Alzheimer's disease or mild cognitive impairment (MCI), there is increasing attention to understanding cognitive decline in normal elderly individuals, with the goal of identifying subjects who are most susceptible to imminent cognitive impairment.

Purpose/hypothesis

To evaluate the potential of cerebral blood flow (CBF) as a biomarker by investigating the relationship between CBF at baseline and cognition at follow-up.

Study type

Prospective longitudinal study with a 4-year time interval.

Population

309 healthy subjects aged 20-89 years old.

Field strength/sequence

3T pseudo-continuous-arterial-spin-labeling MRI.

Assessment

CBF at baseline and cognitive assessment at b

SUBMITTER: De Vis JB 

PROVIDER: S-EPMC6028323 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature