Doxorubicin and anti-VEGF siRNA co-delivery via nano-graphene oxide for enhanced cancer therapy in vitro and in vivo.

ABSTRACT:

Background

Graphene oxide (GO) has attracted intensive interest in biological and medical fields in recent years due to its unique physical, chemical, and biological properties. In our previous work, we proved that GO could deliver small interfering RNA (siRNA) into cells and downregulate the expression of the desired gene.

Methods

This study investigated the potential of a modified GO nanocarrier for co-delivery of siRNA and doxorubicin (DOX) for enhanced cancer therapy. Fourier transform infrared spectroscopy, laser particle size analyzer, UV-visible spectroscopy, gel electrophoresis retardation, and in vitro release assay were studied.

Results

The results of real-time polymerase chain reaction revealed that the expression of vascular endothelial growth factor (VEGF

SUBMITTER: Sun Q 

PROVIDER: S-EPMC6028351 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature