Early alteration of epigenetic-related transcription in Huntington's disease mouse models.

ABSTRACT: Transcriptional dysregulation in Huntington's disease (HD) affects the expression of genes involved in survival and neuronal functions throughout the progression of the pathology. In recent years, extensive research has focused on epigenetic and chromatin-modifying factors as a causative explanation for such dysregulation, offering attractive targets for pharmacological therapies. In this work, we extensively examined the gene expression profiles in the cortex, striatum, hippocampus and cerebellum of juvenile R6/1 and N171-82Q mice, models of rapidly progressive HD, to retrieve the early transcriptional signatures associated with this pathology. These profiles were largely consistent across HD datasets, contained tissular and neuronal-specific genes and showed significant correspondence wi

SUBMITTER: Hervas-Corpion I 

PROVIDER: S-EPMC6028428 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature