Effects of Mild Blast Traumatic Brain Injury on Cognitive- and Addiction-Related Behaviors.

ABSTRACT: Traumatic brain injury (TBI) commonly results in cognitive and psychiatric problems. Cognitive impairments occur in approximately 30% of patients suffering from mild TBI (mTBI), and correlational evidence from clinical studies indicates that substance abuse may be increased following mTBI. However, understanding the lasting cognitive and psychiatric problems stemming from mTBI is difficult in clinical settings where pre-injury assessment may not be possible or accurate. Therefore, we used a previously characterized blast model of mTBI (bTBI) to examine cognitive- and addiction-related outcomes. We previously demonstrated that this model leads to bilateral damage of the medial prefrontal cortex (mPFC), a region critical for cognitive function and addiction. Rats were exposed to bTBI and tes

SUBMITTER: Muelbl MJ 

PROVIDER: S-EPMC6028456 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature