Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling.

ABSTRACT:

Background

Pulmonary pulse wave velocity (PWV) allows the non-invasive measurement of pulmonary arterial stiffening, but has not previously been assessed in COPD. The aim of the current study was to assess PWV in COPD and its association with right ventricular (RV) remodelling.

Methods

Fifty-eight participants with COPD underwent pulmonary function tests, 6-min walk test and cardiac MRI, while 21 healthy controls (HCs) underwent cardiac MRI. Thirty-two COPD patients underwent a follow-up MRI to assess for longitudinal changes in RV metrics. Cardiac MRI was used to quantify RV mass, volumes and PWV. Differences in continuous variables between the COPD and HC groups was tested using an independent t-test, and associations between PWV and right ventricular parameters was examin

SUBMITTER: Weir-McCall JR 

PROVIDER: S-EPMC6028842 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature