Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) have emerged as important regulators of human cancers. However, the functional roles of lncRNAs and the mechanisms responsible for their aberrant expression in gastric cancer (GC) have not been well characterized.

Methods

In this study, we examined the expression of lncRNA UFC1 in GC by qRT-PCR and explored its correlation with clinicopathological parameters. In vitro cell functional assays and in vivo animal studies were performed to determine the roles of UFC1 in GC progression.

Results

UFC1 was elevated and predicted poorer prognosis in GC. UFC1 knockdown inhibited while UFC1 overexpression promoted GC cell proliferation, migration, and invasion. UFC1 bound to miR-498 to antagonize its tumor suppressive effect on Lin28b. Su

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6029056 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature