Peptides derived from the integrin β cytoplasmic tails inhibit angiogenesis.

ABSTRACT:

Background

Integrins are essential regulators of angiogenesis. However, the antiangiogenic potential of peptides derived from the integrin cytoplasmic tails (CT) remains mostly undetermined.

Methods

Here we designed a panel of membrane-penetrating peptides (termed as mβCTPs), each comprising a C-terminal NxxY motif from one of the conserved integrin β CTs, and evaluated their antiangiogenic ability using both in vitro and in vivo approaches.

Results

We found that mβ3CTP, mβ5CTP and mβ6CTP, derived respectively from the integrin β3, β5 and β6 CTs, but not others, exhibit antiangiogenic ability. Interestingly, we observed that the integrin β3, β5 and β6 CTs but not others are able to interact with β₃-endonexin. In addition, the antiangiogenic core in mβ3CTP i

SUBMITTER: Cao Z 

PROVIDER: S-EPMC6029062 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature