The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China.

ABSTRACT:

Background

Primary membranous nephropathy (pMN) is the most common cause of nephrotic syndrome in adults. The discovery of the 2 autoantigens, M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), has defined pMN as an autoimmune disease. A remarkable increase in the frequency of pMN in primary glomerular disease was witnessed in China. The genetic and environmental contributors to disease susceptibility have been investigated in these patients.

Summary

We reviewed recent publications in genetic and environmental studies of pMN, focusing mainly on those undertaken in China. Following a genome-wide association study, the gene-gene interaction between the 2 most significant risk factors, PLA2R1 and DQA1, was validated in Chinese pati

SUBMITTER: Zhang XD 

PROVIDER: S-EPMC6029227 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature