Dataset Information

Antibiotic resistance and molecular characterization of the hydrogen sulfide-negative phenotype among diverse Salmonella serovars in China.

ABSTRACT:

Background

Among 2179 Salmonella isolates obtained during national surveillance for salmonellosis in China from 2005 to 2013, we identified 46 non-H₂S-producing strains originating from different sources.

Methods

The isolates were characterized in terms of antibiotic resistance and genetic variability by pulsed-field gel electrophoresis and multilocus sequence typing. Mutation in the phs operon, which may account for the non-H₂S-producing phenotype of the isolated Salmonella strains, was performed in this study.

Results

Among isolated non-H₂S-producing Salmonella strains, more than 50% were recovered from diarrhea patients, of which H₂S-negative S. Gallinarum, S. Typhimurium, S. Choleraesuis and S. Paratyphi A isolates constituted 76%. H₂S-negative isolates exhibited a high rate of resistance to ticarcillin, ampicillin, and tetracycline, and eight of them had the multidrug resistance phenotype. Most H₂S-negative Salmonella isolates had similar pulsed-field gel electrophoresis profiles and the same sequence type as H₂S-positive strains, indicating a close origin, but carried mutations in the phsA gene, which may account for the non-H₂S-producing phenotype.

Conclusions

Our data indicate that multiple H₂S-negative strains have emerged and persist in China, emphasizing the necessity to implement efficient surveillance measures for controlling dissemination of these atypical Salmonella strains.

SUBMITTER: Xie J

PROVIDER: S-EPMC6029346 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Antibiotic resistance and molecular characterization of the hydrogen sulfide-negative phenotype among diverse Salmonella serovars in China.

Xie Jing J Wu Fuli F Xu Xuebin X Yang Xiaoxia X Zhao Rongtao R Ma Qiuxia Q Li Peng P Wang Ligui L Hao Rongzhang R Jia Leiji L Du Xinying X Qiu Shaofu S Song Hongbin H

BMC infectious diseases 20180703 1

<h4>Background</h4>Among 2179 Salmonella isolates obtained during national surveillance for salmonellosis in China from 2005 to 2013, we identified 46 non-H<sub>2</sub>S-producing strains originating from different sources.<h4>Methods</h4>The isolates were characterized in terms of antibiotic resistance and genetic variability by pulsed-field gel electrophoresis and multilocus sequence typing. Mutation in the phs operon, which may account for the non-H<sub>2</sub>S-producing phenotype of the iso ...[more]

PMID: 29970024

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Dataset Information

Antibiotic resistance and molecular characterization of the hydrogen sulfide-negative phenotype among diverse Salmonella serovars in China.

Background

Methods

Results

Conclusions

Publications

Antibiotic resistance and molecular characterization of the hydrogen sulfide-negative phenotype among diverse Salmonella serovars in China.

Similar Datasets

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