Prognostic significance of the long noncoding RNAs in nasopharyngeal carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Background and objective

Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy. Despite recent advances in treatment, the prognosis, particularly for those at the advanced stages, remains poor. Moreover, the underlying genetic and molecular events have remained obscure so far. Recently, increasing evidence has demonstrated that long noncoding RNAs (lncRNAs) could act as either oncogenes or tumor suppressor genes in various cancers depending on their targets. And some lncRNAs have been shown to be aberrantly expressed in NPC. In this meta-analysis, we try to elucidate the possible role of lncRNAs and their expression on prognosis in NPC.

Methods

We searched the databases of PubMed, Embase, and Web of Science for relevant articles ranging from January 2000 to Dec

SUBMITTER: Guo H 

PROVIDER: S-EPMC6029603 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature