The duration of hypothermia affects short-term neuroprotection in a mouse model of neonatal hypoxic ischaemic injury.

ABSTRACT: Neonatal hypoxic-ischaemic encephalopathy (HIE) is major cause of neonatal mortality and morbidity. Therapeutic hypothermia is standard clinical care for moderate hypoxic-ischaemic (HI) brain injury, however it reduces the risk of death and disability only by 11% and 40% of the treated infants still develop disabilities. Thus it is necessary to develop supplementary therapies to complement therapeutic hypothermia in the treatment of neonatal HIE. The modified Rice-Vannucci model of HI in the neonatal mouse is well developed and widely applied with different periods of hypothermia used as neuroprotective strategy in combination with other agents. However, different studies use different periods, time of initiation and duration of hypothermia following HI, with subsequent varying degrees of

SUBMITTER: Rocha-Ferreira E 

PROVIDER: S-EPMC6029790 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature