Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.

ABSTRACT: Understanding any brain circuit will require a categorization of its constituent neurons. In hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to date. However, this list may be incomplete; additionally, it is unclear whether discrete classes are sufficient to describe the diversity of cortical inhibitory neurons or whether continuous modes of variability are also required. We studied the transcriptomes of 3,663 CA1 inhibitory cells, revealing 10 major GABAergic groups that divided into 49 fine-scale clusters. All previously described and several novel cell classes were identified, with three previously described classes unexpectedly found to be identical. A division into discrete classes, however, was not sufficient to describe the diversity of these cells,

SUBMITTER: Harris KD 

PROVIDER: S-EPMC6029811 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature