Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy.

ABSTRACT: Adoptive T-cell therapy is an effective strategy for cancer immunotherapy. However, infused T cells frequently become functionally exhausted, and consequently offer a poor prognosis after transplantation into patients. Adoptive transfer of tumor antigen-specific stem cell memory T (T_SCM ) cells is expected to overcome this shortcoming as T_SCM cells are close to naïve T cells, but are also highly proliferative, long-lived, and produce a large number of effector T cells in response to antigen stimulation. We previously reported that activated effector T cells can be converted into T_SCM -like cells (iT_SCM ) by coculturing with OP9 cells expressing Notch ligand, Delta-like 1 (OP9-hDLL1). Here we show the methodological parameters of human CD8^+</

SUBMITTER: Kondo T 

PROVIDER: S-EPMC6029822 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature