Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats.

ABSTRACT: Potassium octatitanate fibers (K₂ O·8TiO₂ , POT fibers) are widely used as an alternative to asbestos. We investigated the pulmonary and pleural toxicity of POT fibers with reference to 2 non-fibrous titanium dioxide nanoparticles (nTiO₂ ), photoreactive anatase (a-nTiO₂ ) and inert rutile (r-nTiO₂ ). Ten-week-old male F344 rats were given 0.5 mL of 250 μg/mL suspensions of POT fibers, a-nTiO₂ , or r-nTiO₂ , 8 times (1 mg/rat) over a 15-day period by trans-tracheal intrapulmonary spraying (TIPS). Rats were killed at 6 hours and at 4 weeks after the last TIPS dose. Alveolar macrophages were significantly increased in all treatment groups at 6 hours and at 4 weeks. At week 4, a-nTiO₂ and r-nTiO₂

SUBMITTER: Abdelgied M 

PROVIDER: S-EPMC6029824 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature