The cortisol:C-reactive protein ratio and negative affect reactivity in depressed adults.

ABSTRACT:

Objective

We evaluated the effect of the cortisol (CORT) to high sensitivity C-reactive protein (hsCRP) ratio on stress-induced negative affect (NA) reactivity and whether the association was moderated by depressive symptom severity and gender. The CORT/CRP ratio was used to evaluate the integrity of the negative feedback loop between the hypothalamic-pituitary-adrenal axis and inflammatory response system.

Method

Basal CORT and hsCRP levels were measured in fasting blood samples from 198 medication-free and nonsmoking healthy men and women. Depressive symptom severity was assessed using the Hamilton Rating Scale for Depression (HAMD). NA ratings were collected at baseline and at the completion of the laboratory stressors, the Anger Recall Interview (ARI) and reading.

Res

SUBMITTER: Suarez EC 

PROVIDER: S-EPMC6029876 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature