Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production.

ABSTRACT: The production of cytokines in response to DNA-damage events may be an important host defense response to help prevent the escape of pre-cancerous cells. The innate immune pathways involved in these events are known to be regulated by cellular molecules such as stimulator of interferon genes (STING), which controls type I interferon and pro-inflammatory cytokine production in response to the presence of microbial DNA or cytosolic DNA that has escaped from the nucleus. STING signaling has been shown to be defective in a variety of cancers, such as colon cancer and melanoma, actions that may enable damaged cells to escape the immunosurveillance system. Here, we report through examination of databases that STING signaling may be commonly suppressed in a greater variety of tumors due to loss-o

SUBMITTER: Konno H 

PROVIDER: S-EPMC6029885 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature