Comprehensive meta-analysis reveals association between multiple imprinting disorders and conception by assisted reproductive technology.

ABSTRACT:

Purpose

To determine whether a history of conception by assisted reproductive technology (ART) is associated with occurrence of one or more imprinting disorders of either maternal or paternal origin.

Methods

We implemented a systematic review of scholarly literature followed by comprehensive meta-analysis to quantitatively synthesize data from reports relating to use of ART to occurrence of any imprinting disorder of humans, including Beckwith-Wiedemann (BWS), Angelman (AS), Prader-Willi (PWS), and Silver-Russell (SRS) syndromes, as well as transient neonatal diabetes mellitus (TNDB) and sporadic retinoblasoma (RB).

Results

The systematic review identified 13 reports presenting unique data from 23 studies that related conception following ART to occurrence of imprinti

SUBMITTER: Cortessis VK 

PROVIDER: S-EPMC6030010 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature