Genetic association study from North India to analyze association of CYP19A1 and CYP17A1 with polycystic ovary syndrome.

ABSTRACT: PURPOSE:Polycystic ovary syndrome (PCOS) is a complex multifactorial endocrine disorder affecting approximately 5-10% of women of reproductive age. Affected women have menstrual disturbances due to anovulation, infertility, and hyperandrogenism. Ovarian androgen overproduction is the key physiopathologic feature of PCOS. A number of genes encoding major enzymes of the androgen metabolic pathways, such as HSD17B6, CYP19A1, CYP11A1, CYP17A1, and INSR, have been examined. Very few studies have been done in North India. There is an increasing prevalence of PCOS in women in Punjab and it is the leading cause of female infertility. In view of the strong evidence implicating the importance of CYP19A1 and CYP17A1 in androgen metabolic pathways, we investigated the association of rs700519, rs241409

SUBMITTER: Kaur R 

PROVIDER: S-EPMC6030014 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature