Development of optokinetic tracking software for objective evaluation of visual function in rodents.

ABSTRACT: The aim of this study was to develop software that performs the optokinetic tracking assessment without the involvement of experimenters to increase the objectivity of the test. To check the effectiveness of the software, several videos were analyzed and the results were compared to those produced by two experimenters. Videos consisted of visual acuity and contrast sensitivity tests on normal animals and pigmented P23H rats (animal model of retinitis pigmentosa). Our software showed a reasonably high success rate: in approximately 78% of the cases, both the software program and the experimenters were in agreement, including the direction of rotation. The software detected 7% false positive cases, 10% false negative cases, and it was wrong in 5% of the cases. Decrease in visual function wit

SUBMITTER: Segura F 

PROVIDER: S-EPMC6030196 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature