Pyocyanin Restricts Social Cheating in Pseudomonas aeruginosa.

ABSTRACT: Quorum sensing (QS) in Pseudomonas aeruginosa coordinates the expression of virulence factors, such as exoproteases and siderophores, that are public goods utilized by the whole population of bacteria, regardless of whether they invested or not in their production. These public goods can be used by QS defective mutants for growth, and since these mutants do not contribute to public goods production, they are considered social cheaters. Pyocyanin is a phenazine that is a toxic, QS-controlled metabolite produced by P. aeruginosa. It is a redox-active compound and promotes the generation of reactive oxygen species; it also possesses antibacterial properties and increases fitness in competition with other bacterial species. Since QS-deficient individuals are less able to tolerate

SUBMITTER: Castaneda-Tamez P 

PROVIDER: S-EPMC6030374 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature