Quantitative susceptibility mapping in combination with water-fat separation for simultaneous liver iron and fat fraction quantification.

ABSTRACT:

Purposes

To evaluate the feasibility of simultaneous quantification of liver iron concentration (LIC) and fat fraction (FF) using water-fat separation and quantitative susceptibility mapping (QSM).

Methods

Forty-five patients suspected of liver iron overload (LIO) were included. A volumetric interpolated breath-hold examination sequence for QSM and FF, a fat-saturated gradient echo sequence for R₂^*, a spin echo sequence for LIC measurements and MRS analyses for FF (FF-MRS) were performed. Magnetic susceptibility and FF were calculated using a water-fat separation method (FF-MRI). Correlation and receiver operating characteristic analyses were performed.

Results

Magnetic susceptibility showed strong correlation with LIC (r_s=0.918). The

SUBMITTER: Lin H 

PROVIDER: S-EPMC6030453 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature