Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques.

ABSTRACT: It is unknown whether the gut microbiome affects HIV transmission. In our recent SHIV vaccine study, we found that the naive rhesus macaques from two different sources had significantly different rates of infection against repeated low-dose intrarectal challenge with SHIV_SF162P4 virus. Exploring causes, we found that the more susceptible group of seven macaques had significantly more activated CD4⁺CCR5⁺Ki67⁺ T cells in the rectal mucosa than the more resistant group of 11 macaques from a different source. The prevalence of pre-challenge activated rectal CD4 T cells in the naive macaques correlated inversely with the number of challenges required to infect. Because the two naive groups came from different sources, we hypothesized that their microb

SUBMITTER: Sui Y 

PROVIDER: S-EPMC6030500 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature