Activation of Notch-1 in oral epithelial cells by P. gingivalis triggers the expression of the antimicrobial protein PLA₂-IIA.

ABSTRACT: P. gingivalis (Pg) is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which mucosal responses to the oral microbiota in the presence of specific pathogens such as Pg could abrogate the host-microbe symbiotic relationship leading to periodontitis remain unclear. Herein, we identified the Notch-1/PLA₂-IIA axis as a new molecular pathway through which Pg could be specifically modulating oral epithelial antimicrobial and inflammatory responses. Pg activated Notch-1, and inhibition or silencing of Notch-1 completely abrogated Pg-induced PLA₂-IIA in oral epithelial cells (OECs). Activation of Notch-1 and PLA₂-IIA production were associated with Pg-produced gingipains. Other oral Gram-positive and

SUBMITTER: Al-Attar A 

PROVIDER: S-EPMC6030509 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature