The relative fitness of drug-resistant Mycobacterium tuberculosis: a modelling study of household transmission in Peru.

ABSTRACT: The relative fitness of drug-resistant versus susceptible bacteria in an environment dictates resistance prevalence. Estimates for the relative fitness of resistant Mycobacterium tuberculosis (Mtb) strains are highly heterogeneous and mostly derived from in vitro experiments. Measuring fitness in the field allows us to determine how the environment influences the spread of resistance. We designed a household structured, stochastic mathematical model to estimate the fitness costs associated with multidrug resistance (MDR) carriage in Mtb in Lima, Peru during 2010-2013. By fitting the model to data from a large prospective cohort study of TB disease in household contacts, we estimated the fitness, relative to susceptible strains with a fitness of 1, of MDR-Mtb to be 0.32 (95% credible interv

SUBMITTER: Knight GM 

PROVIDER: S-EPMC6030636 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature