Antithetic proportional-integral feedback for reduced variance and improved control performance of stochastic reaction networks.

ABSTRACT: The ability of a cell to regulate and adapt its internal state in response to unpredictable environmental changes is called homeostasis and this ability is crucial for the cell's survival and proper functioning. Understanding how cells can achieve homeostasis, despite the intrinsic noise or randomness in their dynamics, is fundamentally important for both systems and synthetic biology. In this context, a significant development is the proposed antithetic integral feedback (AIF) motif, which is found in natural systems, and is known to ensure robust perfect adaptation for the mean dynamics of a given molecular species involved in a complex stochastic biomolecular reaction network. From the standpoint of applications, one drawback of this motif is that it often leads to an increased cell-to-

SUBMITTER: Briat C 

PROVIDER: S-EPMC6030643 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature