Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection.

ABSTRACT: Purpose: Stem cell transplants are an effective approach to repair large bone defects. However, comprehensive techniques to monitor the fate of transplanted stem cells in vivo are lacking. Such strategies would enable corrective interventions at an early stage and greatly benefit the development of more successful tissue regeneration approaches. In this study, we designed and synthesized a dual-modality imaging probe (Feru-AFC) that can simultaneously localize transplanted stem cells and diagnose immune rejection-induced apoptosis at an early stage in vivo. Methods: We used a customized caspase-3 cleavable peptide-dye conjugate to modify the surface of clinically approved ferumoxytol nanoparticles (NPs) to generate the dual-modality imaging probe with fluorescen

SUBMITTER: Li K 

PROVIDER: S-EPMC6030766 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature