Postoperative cellular stress in the kidney is associated with an early systemic γδ T-cell immune cell response.

ABSTRACT:

Background

Basic science data suggest that acute kidney injury (AKI) induced by ischemia-reperfusion injury (IRI) is an inflammatory process involving the adaptive immune response. Little is known about the T-cell contribution in the very early phase, so we investigated if tubular cellular stress expressed by elevated cell cycle biomarkers is associated with early changes in circulating T-cell subsets, applying a bedside-to-bench approach.

Methods

Our observational pilot study included 20 consecutive patients undergoing endovascular aortic repair for aortic aneurysms affecting the renal arteries, thereby requiring brief kidney hypoperfusion and reperfusion. Clinical-grade flow cytometry-based immune monitoring of peripheral immune cell populations was conducted perioperative

SUBMITTER: Gocze I 

PROVIDER: S-EPMC6030780 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature