Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population.

ABSTRACT:

Background

Genetic changes in p53 gene contribute to breast cancer susceptibility.

Objective and methods

A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women.

Results

p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence.

Conclusion

The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian

SUBMITTER: Akhter N 

PROVIDER: S-EPMC6030857 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature