Transcriptome Sequencing Reveals Candidate NF-κB Target Genes Involved in Repeated Cocaine Administration.

ABSTRACT:

Background

Drug-induced alterations in gene expression play an important role in the development of addictive behavior. Numerous transcription factors have been implicated in mediating the gene expression changes that occur in drug addiction. Nuclear factor kappa B is an inducible transcription factor complex that is rapidly activated by diverse stimuli.

Methods

We performed next-generation high-throughput sequencing of the prefrontal cortex in a mouse model of repeated cocaine administration combined with pharmacological nuclear factor kappa B inhibition to identify nuclear factor kappa B target genes that participate in the cocaine addiction process.

Results

We found that the nuclear factor kappa B antagonist sodium diethyldithiocarbamate trihydrate significantly re

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6030870 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature