Infectivity of Chronic Malaria Infections and Its Consequences for Control and Elimination.

ABSTRACT: Assessing the importance of targeting the chronic Plasmodium falciparum malaria reservoir is pivotal as the world moves toward malaria eradication. Through the lens of a mathematical model, we show how, for a given malaria prevalence, the relative infectivity of chronic individuals determines what intervention tools are predicted be the most effective. Crucially, in a large part of the parameter space where elimination is theoretically possible, it can be achieved solely through improved case management. However, there are a significant number of settings where malaria elimination requires not only good vector control but also a mass drug administration campaign. Quantifying the relative infectiousness of chronic malaria across a range of epidemiological settings would provide essential in

SUBMITTER: Aguas R 

PROVIDER: S-EPMC6030896 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature