MTM-align: a server for fast protein structure database search and multiple protein structure alignment.

ABSTRACT: With the rapid increase of the number of protein structures in the Protein Data Bank, it becomes urgent to develop algorithms for efficient protein structure comparisons. In this article, we present the mTM-align server, which consists of two closely related modules: one for structure database search and the other for multiple structure alignment. The database search is speeded up based on a heuristic algorithm and a hierarchical organization of the structures in the database. The multiple structure alignment is performed using the recently developed algorithm mTM-align. Benchmark tests demonstrate that our algorithms outperform other peering methods for both modules, in terms of speed and accuracy. One of the unique features for the server is the interplay between database search and mult

SUBMITTER: Dong R 

PROVIDER: S-EPMC6030909 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature